Humanin
10MG24-residue mitochondrial-derived peptide.
6 peer-reviewed citations for this compound
Read the sourcesVolume tiers count vials of this compound at this strength. Mixing different compounds does not combine toward a tier.
- ≥99% purity specification
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- Research use only
Released against a ≥99% HPLC purity specification and supplied as a sealed laboratory reagent for in vitro research use only.
- Type
- Mitochondrial-derived peptide
- Amino acids
- 24
- Form
- Lyophilized powder
- Vial strength
- 10MG
- Purity specification
- ≥99% by HPLC
Identifiers are published properties of the molecule. Values we cannot confirm are omitted rather than estimated.
Dispatch
Ships within 1 business day of order confirmation, from the US. Vials ship lyophilized at ambient temperature; move them to the storage condition below on arrival.
Lyophilized
Store at -20°C, protected from light. Stable 24+ months sealed.
Reconstituted
Store at 2-8°C. Use within approximately 30 days.
How Humanin is described to act.
Humanin is a 24-residue peptide encoded by a short open reading frame in the mitochondrial 16S rRNA gene (MT-RNR2) and was the first mitochondrial-derived peptide described. In vitro single-molecule fluorescence and Forster resonance energy transfer experiments in lipid bilayers report that humanin binds Bax and truncated Bid, inhibits Bax self-association and tBid-activated Bax membrane association, and decreases the proportion of Bax present as tetramers, thereby limiting mitochondrial membrane permeability and intrinsic apoptosis. Review literature additionally describes humanin acting extracellularly through cell-surface receptor complexes and reports inhibition of mitochondrial complex I activity with a corresponding reduction in cellular oxidative stress. Humanin expression is reported in several tissues with high metabolic rate and, in brain, in glial cells including astrocytes.
Mechanistic descriptions summarize published in vitro and animal work. They are not a representation of efficacy or safety in any subject, and no administration guidance is given or implied.
In Caenorhabditis elegans, humanin overexpression was reported to increase lifespan in a manner dependent on daf-16/FOXO, and humanin transgenic mice displayed overlapping phenotypes with greater protection against toxic insults. Twice-weekly treatment of middle-aged mice with the potent humanin analogue HNG was reported to alter metabolic healthspan parameters and reduce inflammatory markers. In a rodent surgical menopause model, astrocyte-released humanin was reported to prevent synapse loss in hippocampal neurons. Observational human and cross-species data indicate that circulating humanin generally declines with age, that levels were stable in the naked mole-rat, and that children of centenarians showed higher circulating humanin than age-matched controls. Cardiovascular and energy-metabolism reviews discuss humanin as a candidate marker of mitochondrial function; no controlled human intervention trial of humanin appears in this citation set.
Sources & references
Cited literature is provided for scientific reference only and does not constitute a representation of efficacy or safety in any subject. All research findings presented are sourced from peer-reviewed journals and are provided for educational reference only.
- 01The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Yen K, et al. · Aging (Albany NY), 2020
- 02Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders
Rochette L, et al. · Arch Cardiovasc Dis, 2020
- 03Mitochondrial-derived peptides in energy metabolism
Merry TL, et al. · Am J Physiol Endocrinol Metab, 2020
- 04Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons
Zárate SC, et al. · Front Aging Neurosci, 2019
- 05
- 06The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Yen K, et al. · J Mol Endocrinol, 2013
Every entry links to its record at the publisher or on PubMed. Titles are reproduced exactly as published.
Further searches
Live database searches for Humanin, run against the current index and retrieved independently of this site.
Bench handling, not a dosing guide.
Intended use
Supplied exclusively as a research reagent for in vitro and laboratory use by qualified researchers. Not a drug, dietary supplement, cosmetic or medical device, and not for human or veterinary use. No dosing, route or administration guidance is provided for any compound in this catalog.
Personal protection
Handle in a controlled laboratory environment with gloves and eye protection. Avoid generating or inhaling airborne particulate when opening a vial, and do not handle the material outside a designated work area.
Opening and reconstitution
Lyophilized peptides are hygroscopic. Let the sealed vial equilibrate to room temperature before opening so atmospheric moisture does not condense onto the powder. Reconstitute by directing diluent down the vial wall and swirling until dissolved — do not shake, which shears and foams the peptide.
Stability and aliquoting
Store at -20°C, protected from light. Stable 24+ months sealed. Store at 2-8°C. Use within approximately 30 days. Aliquot reconstituted material and minimize repeated freeze-thaw cycles.
Waste disposal
Dispose of unused material, reconstituted solutions and sharps through your institution's chemical and biological waste stream, in accordance with local regulations. Do not dispose of research material in domestic waste or to drain.
Others in longevity & cellular
Epithalon
Synthetic tetrapeptide Ala-Glu-Asp-Gly.
FOXO4
FOXO4-p53 interfering peptide, D-retro-inverso.
Glutathione
Reduced L-glutathione tripeptide.
NAD+
Nicotinamide adenine dinucleotide, oxidized.
Important research notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
This material is supplied exclusively as a research reagent for in vitro and laboratory use by qualified researchers. It is not a drug, dietary supplement, cosmetic, or medical device, is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No dosing, administration, therapeutic, or benefit claims are made or implied. Cited literature is provided for scientific reference only and does not constitute a representation of efficacy or safety in any subject.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.