MOTS-C
40MG16-residue mitochondrial-derived peptide.
6 peer-reviewed citations for this compound
Read the sourcesVolume tiers count vials of this compound at this strength. Mixing different compounds does not combine toward a tier.
- ≥99% purity specification
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- Research use only
Released against a ≥99% HPLC purity specification and supplied as a sealed laboratory reagent for in vitro research use only.
- Type
- Mitochondrial-derived peptide
- CAS number
- 1627580-64-7
- Amino acids
- 16
- Form
- Lyophilized powder
- Vial strength
- 40MG
- Purity specification
- ≥99% by HPLC
Identifiers are published properties of the molecule. Values we cannot confirm are omitted rather than estimated.
Dispatch
Ships within 1 business day of order confirmation, from the US. Vials ship lyophilized at ambient temperature; move them to the storage condition below on arrival.
Lyophilized
Store at -20°C, protected from light. Stable 24+ months sealed.
Reconstituted
Store at 2-8°C. Use within approximately 30 days.
How MOTS-C is described to act.
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene (MT-RNR1), identified as the second described member of the mitochondrial-derived peptide family. In cultured cells and rodent tissue it is reported to inhibit the folate cycle and its tethered de novo purine biosynthesis, producing AICAR accumulation and AMPK activation, with skeletal muscle described as the apparent primary target organ. Under metabolic stress such as glucose restriction, MOTS-c has been shown to translocate from mitochondria to the nucleus in an AMPK-dependent manner and to interact with antioxidant response element (ARE)-regulating stress-responsive transcription factors including NFE2L2/NRF2, a proposed retrograde mitochondrial-to-nuclear signaling route. Separate rodent adipose work attributes thermogenic gene induction to MOTS-c-associated ERK phosphorylation.
Mechanistic descriptions summarize published in vitro and animal work. They are not a representation of efficacy or safety in any subject, and no administration guidance is given or implied.
In the original characterization, MOTS-c administration to mice was reported to prevent age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity. Follow-up rodent work reported that cold exposure lowered serum MOTS-c and that MOTS-c treatment upregulated brown adipose thermogenic gene expression, increased white adipose browning, and reduced lipid trafficking to the liver. In a transverse aortic constriction mouse model of pressure-overload heart failure, subcutaneous MOTS-c delivered by osmotic pump was associated with attenuated cardiac dysfunction and remodelling, reduced inflammatory response and increased antioxidant capacity alongside AMPK pathway activation, while MOTS-c overexpression reduced H2O2-induced death in cultured H9C2 cardiac cells. Review articles in this set describe endogenous MOTS-c expression as responsive to exercise and metabolic stress, with circulating levels generally lower in aging and metabolic disease. Human data across these citations are observational or expression-level; no controlled clinical efficacy trial of MOTS-c is represented here.
Sources & references
Cited literature is provided for scientific reference only and does not constitute a representation of efficacy or safety in any subject. All research findings presented are sourced from peer-reviewed journals and are provided for educational reference only.
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- 05MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
Lee C, et al. · Free Radic Biol Med, 2016
- 06
Every entry links to its record at the publisher or on PubMed. Titles are reproduced exactly as published.
Further searches
Live database searches for MOTS-C, run against the current index and retrieved independently of this site.
Bench handling, not a dosing guide.
Intended use
Supplied exclusively as a research reagent for in vitro and laboratory use by qualified researchers. Not a drug, dietary supplement, cosmetic or medical device, and not for human or veterinary use. No dosing, route or administration guidance is provided for any compound in this catalog.
Personal protection
Handle in a controlled laboratory environment with gloves and eye protection. Avoid generating or inhaling airborne particulate when opening a vial, and do not handle the material outside a designated work area.
Opening and reconstitution
Lyophilized peptides are hygroscopic. Let the sealed vial equilibrate to room temperature before opening so atmospheric moisture does not condense onto the powder. Reconstitute by directing diluent down the vial wall and swirling until dissolved — do not shake, which shears and foams the peptide.
Stability and aliquoting
Store at -20°C, protected from light. Stable 24+ months sealed. Store at 2-8°C. Use within approximately 30 days. Aliquot reconstituted material and minimize repeated freeze-thaw cycles.
Waste disposal
Dispose of unused material, reconstituted solutions and sharps through your institution's chemical and biological waste stream, in accordance with local regulations. Do not dispose of research material in domestic waste or to drain.
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Important research notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
This material is supplied exclusively as a research reagent for in vitro and laboratory use by qualified researchers. It is not a drug, dietary supplement, cosmetic, or medical device, is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No dosing, administration, therapeutic, or benefit claims are made or implied. Cited literature is provided for scientific reference only and does not constitute a representation of efficacy or safety in any subject.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.